Biomolecular Structure and Function
The three-dimensional structures of biological molecules and their complexes provide the fundamental basis for understanding how they mediate their functions.

Through the use of techniques including NMR, x-ray crystallography, mass spectrometry, CD and fluorescence spectroscopy, sedimentation analysis, and computational approaches, we are studying structure-function relationships in a number of important areas. Included among these are protein and membrane-protein structure, protein-protein and protein-ligand interactions, protein folding, stability and dynamics, and enzyme specificity and catalysis.

In addition to providing insight into the principles upon which complex biological systems are based, our work has long-term applications in the biotechnology and health care sectors.


 Faculty currently doing research in this area:
J.W. Callahan Professor Emeritus
Inborn Errors of Lysosomes
Hospital for Sick Children, Research Institute, Room 9144
H.S. Chan
Theoretical and Computational Approaches to Protein Folding
Medical Sciences Building, Room 5363
A. Davidson
In Vitro and In Vivo Studies of Protein-Protein Interactions and Macromolecular Assembly
Medical Sciences Building, Room 4285
C.M. Deber
Protein Structure in Membrane Domains
Hospital for Sick Children, Research Institute, Room 3427A
J. Forman-Kay
Protein Structure, Dynamics and Folding by NMR Method
Hospital for Sick Children, Research Institute, Room 3401
J.R. Glover
Molecular Chaperones
Medical Sciences Building, Room 5302
W.A. Houry
Chaperones in Protein Folding and Degradation
Medical Sciences Building, Room 5308
P.L. Howell
Macromolecular Complexes Involved in Bacterial Biofilm Formation
Hospital for Sick Children, Research Institute, Room 3427B
D.E. Isenman Professor Emeritus
Structure-Function Relations in Proteins of the Complement System
Medical Sciences Building, Room 5306
L. Kay
Development and Application of NMR Methods for The Study of Protein Structure and Dynamics
McMurrich Building, Room 1233
F.W. Keeley
Synthesis and Assembly of Elastin and Elastin-Like Structural Proteins of the Extracellular Matrix
Hospital for Sick Children, McMaster Building, Room 7003
C.A. Lingwood
Receptor Function of Glycolipids
Hospital for Sick Children, Research Institute, Room 7114
M.F. Manolson
Assembly, Targeting, and Control of Proton Pumping V-ATPases
Faculty of Dentistry, 124 Edward Street Room 403
416-979-4900 #4392
R. Melnyk
Bacterial Pathogenesis: Molecular Mechanisms and Therapeutic Approaches
Hospital for Sick Kids, Room 3203A
416-813-7654 x28557
T.F. Moraes
Structure and Function of Ion and Protein Translocation Machineries
Medical Sciences Building, Room 5366
E.F. Pai
Structure and Function of Proteins
Medical Sciences Building, Room 5358
R. Pomès
Theoretical Methods Applied to the Structure, Function and Dynamics of Biological Macromolecules
Hospital for Sick Children, Research Institute, Room 3405
G. Privé
Protein Structure and X-Ray Crystallography
MaRS Toronto Medical Discovery Tower Room 4-302
R.S. Prosser
Protein Structure and Dynamics - Energy Landscapes and Folding Pathways
University of Toronto, Mississauga, South Building, 4052
D.E. Pulleyblank
Role of DNA Conformation in Regulation of Gene Expression
Medical Sciences Building, Room 5233
R. Reithmeier
Structure and Function of Membrane Proteins
Medical Sciences Building, Room 5242
J.M. Rini
Protein Structure and Molecular Recognition
Medical Sciences Building, Room 5360
B.H. Robinson Professor Emeritus
Inborn Error in Man: Chronic Childhood Lacticacidemia
Hospital for Sick Children, Research Institute, Room 9146C
J. Rubinstein
Electron cryomicroscopy of macromolecular assemblies

Molecular Structure and Function Program, Hospital for Sick Children, Research Institute, Room 20-9705
B. Sarkar Professor Emeritus
DNA-Binding Proteins and Proteins of Metal Transport: Structure and Function
Hospital for Sick Children, Research Institute, Room 3427
H. Schachter Professor Emeritus
Structure and Synthesis of Glycoproteins
Hospital for Sick Children, Research Institute, Room 3427B
S. Sharpe
Structure and assembly of membrane-active proteins and peptides by solid-state NMR
Hospital for Sick Children, Research Institute, Room 3503
F. Sicheri
Structural Biology of Eukaryotic Signal Transduction
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
B. Steipe
Informational Protein Folding
Medical Sciences Building, Room 5368
D.B. Williams
Protein Folding & Quality Control
within the Endoplasmic Reticulum

Medical Sciences Building, Room 5316
S. Wodak
Computational Structural Biology and Bioinformatics: Linking the molecular and cellular levels
Hospital for Sick Children, Research Institute, 180 Dundas Street, Suite 1300
C.M. Yip
Biomolecular Engineering at Interfaces
Donnelly Centre for Cellular and Biomolecular Research (CCBR) Room 404

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Department of Biochemistry
University of Toronto
Toronto, Canada

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