Biomolecular Structure and Function
The three-dimensional structures of biological molecules and their complexes provide the fundamental basis for understanding how they mediate their functions.

Through the use of techniques including NMR, x-ray crystallography, mass spectrometry, CD and fluorescence spectroscopy, sedimentation analysis, and computational approaches, we are studying structure-function relationships in a number of important areas. Included among these are protein and membrane-protein structure, protein-protein and protein-ligand interactions, protein folding, stability and dynamics, and enzyme specificity and catalysis.

In addition to providing insight into the principles upon which complex biological systems are based, our work has long-term applications in the biotechnology and health care sectors.

 

 Faculty currently doing research in this area:
J.W. Callahan Professor Emeritus
Inborn Errors of Lysosomes
Hospital for Sick Children, Research Institute, Room 9144
416-813-5754 john.callahan@sickkids.ca
H.S. Chan
Theoretical and Computational Approaches to Protein Folding
Medical Sciences Building, Room 5363
416-978-2697 chan@arrhenius.med.utoronto.ca
A. Davidson
In Vitro and In Vivo Studies of Protein-Protein Interactions and Macromolecular Assembly
Medical Sciences Building, Room 4285
416-978-0332 alan.davidson@utoronto.ca
C.M. Deber
Protein Structure in Membrane Domains
Hospital for Sick Children, Research Institute, Room 3427A
416-813-5924 deber@sickkids.ca
J. Forman-Kay
Protein Structure, Dynamics and Folding by NMR Method
Hospital for Sick Children, Research Institute, Room 3401
416-813-5358 forman@sickkids.ca
J.R. Glover
Molecular Chaperones
Medical Sciences Building, Room 5302
416-978-3008 john.glover@utoronto.ca
W.A. Houry
Chaperones in Protein Folding and Degradation
Medical Sciences Building, Room 5308
416-946-7141 walid.houry@utoronto.ca
P.L. Howell
Macromolecular Complexes Involved in Bacterial Biofilm Formation
Hospital for Sick Children, Research Institute, Room 3427B
416-813-5378 howell@sickkids.ca
D.E. Isenman Professor Emeritus
Structure-Function Relations in Proteins of the Complement System
Medical Sciences Building, Room 5306
416-978-2703 d.isenman@utoronto.ca
L. Kay
Development and Application of NMR Methods for The Study of Protein Structure and Dynamics
McMurrich Building, Room 1233
416-978-0741 kay@pound.med.utoronto.ca
F.W. Keeley
Synthesis and Assembly of Elastin and Elastin-Like Structural Proteins of the Extracellular Matrix
Hospital for Sick Children, McMaster Building, Room 7003
416-813-6704 fwk@sickkids.ca
C.A. Lingwood
Receptor Function of Glycolipids
Hospital for Sick Children, Research Institute, Room 7114
416-813-5998 cling@sickkids.ca
M.F. Manolson
Assembly, Targeting, and Control of Proton Pumping V-ATPases
Faculty of Dentistry, 124 Edward Street Room 403
416-979-4900 #4392 m.manolson@utoronto.ca
R. Melnyk
Bacterial Pathogenesis: Molecular Mechanisms and Therapeutic Approaches
Hospital for Sick Kids, Room 3203A
416-813-7654 x28557 roman.melnyk@sickkids.ca
T.F. Moraes
Structure and Function of Ion and Protein Translocation Machineries
Medical Sciences Building, Room 5366
416-946-3048 trevor.moraes@utoronto.ca
E.F. Pai
Structure and Function of Proteins
Medical Sciences Building, Room 5358
416-978-7015 pai@hera.med.utoronto.ca
R. Pomès
Theoretical Methods Applied to the Structure, Function and Dynamics of Biological Macromolecules
Hospital for Sick Children, Research Institute, Room 3405
416-813-5686 pomes@sickkids.ca
G. Privé
Protein Structure and X-Ray Crystallography
MaRS Toronto Medical Discovery Tower Room 4-302
416-581-7541 prive@uhnres.utoronto.ca
R.S. Prosser
Protein Structure and Dynamics - Energy Landscapes and Folding Pathways
University of Toronto, Mississauga, South Building, 4052
905-828-3802
scott.prosser@utoronto.ca
D.E. Pulleyblank
Role of DNA Conformation in Regulation of Gene Expression
Medical Sciences Building, Room 5233
416-978-8565 david.pulleyblank@utoronto.ca
R. Reithmeier
Structure and Function of Membrane Proteins
Medical Sciences Building, Room 5242
416-978-7739 r.reithmeier@utoronto.ca
J.M. Rini
Protein Structure and Molecular Recognition
Medical Sciences Building, Room 5360
416-978-0557 james.rini@utoronto.ca
B.H. Robinson Professor Emeritus
Inborn Error in Man: Chronic Childhood Lacticacidemia
Hospital for Sick Children, Research Institute, Room 9146C
416-813-5989 bhr@sickkids.on.ca
 
J. Rubinstein
Electron cryomicroscopy of macromolecular assemblies

Molecular Structure and Function Program, Hospital for Sick Children, Research Institute, Room 20-9705
416-813-7255 john.rubinstein@utoronto.ca
B. Sarkar Professor Emeritus
DNA-Binding Proteins and Proteins of Metal Transport: Structure and Function
Hospital for Sick Children, Research Institute, Room 3427
416-813-5921 Bibudhendra.Sarkar@sickkids.ca
H. Schachter Professor Emeritus
Structure and Synthesis of Glycoproteins
Hospital for Sick Children, Research Institute, Room 3427B
416-813-5915 harry@sickkids.on.ca
S. Sharpe
Structure and assembly of membrane-active proteins and peptides by solid-state NMR
Hospital for Sick Children, Research Institute, Room 3503
416-813-7852 ssharpe@sickkids.ca
F. Sicheri
Structural Biology of Eukaryotic Signal Transduction
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
416-586-8471 sicheri@lunenfeld.ca
Boris Steipe
Bioinformatics
Medical Sciences Building, Room 5271
416-946-7741 boris.steipe@utoronto.ca
D.B. Williams
Protein Folding & Quality Control
within the Endoplasmic Reticulum

Medical Sciences Building, Room 5316
416-978-2546 david.williams@utoronto.ca
S. Wodak
Computational Structural Biology and Bioinformatics: Linking the molecular and cellular levels
Hospital for Sick Children, Research Institute, 180 Dundas Street, Suite 1300
416-813-6351shoshana@sickkids.ca
C.M. Yip
Biomolecular Engineering at Interfaces
Donnelly Centre for Cellular and Biomolecular Research (CCBR) Room 404
416-978-7853 christopher.yip@utoronto.ca
 

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Department of Biochemistry
University of Toronto
Toronto, Canada

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